2024: A Year of Scientific Excellence for X‑Chem
One of the best parts of being part of X-Chem is seeing all the great science being conducted around the...
The Importance of Selecting the Right CRO Partners for Drug Discovery Success
When it comes to drug discovery and development, having the right team and partners is critical for success. For a...
AI-Powered Building Blocks “ReadiBLOX” for DEL Synthesis
Drug Hunter recently wrote the article “Decoding DNA-Encoded Libraries for Drug Discovery.” Over the past two decades, DEL technology has...
Flow Chemistry for Contemporary Isotope Labeling
Isotope-labeled compounds have emerged as important tools in drug discovery and development. The incorporated isotopes, particularly deuterium, in pharmaceuticals, have...
Driving Discovery Through Miniaturized High-Throughput Chemistry
When chemists approach the formation of a new bond, they often choose reaction conditions that they (or their colleagues) are...
Refining covalent warhead reactivity: A new look at GSH reactivity assays
If the bond is forever, it needs to be safe. Covalent drugs have proved to be successful therapies for various...
Log KIAM Is the New LogD
By Johan Bartholomeus, Senior Principal Scientist, and Philippe McGee, Principal Scientist In a drug discovery project, during the hit-to-lead and...
X‑Chem and the SGC are pioneering crowd-sourced AI advancements by making DEL screening data public
Artificial intelligence (AI) is now recognized as an indispensable component of the modern drug discovery tool kit, applied at all...
Unlocking Chemical Space: The Power of DEL Screening
Most readers will be familiar with the parable of the “drunkard’s search”, in which a drunk person searches for their...
Success Stories of DEL Enablement
X-Chem’s primary mission has always been to leverage the world’s leading drug discovery platform to help create molecules that will...