The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery
Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...
DEL Screen Artifacts: How to Find and Avoid Them
As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...
DEL Technology and Targeted Protein Degradation Discovery
Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...
Protein-Protein Interactions: A Key to Precision Medicine
Protein-protein interactions (PPIs) are the foundation of life, controlling everything from cell growth and division to metabolism and signaling.1 Targeting...
Going Beyond Hit ID With Machine Learning & Del: The Prediction of Building Block Reactivity
Since X-Chem and Google’s seminal collaboration applying machine learning (ML) to DNA-encoded chemical library (DEL) screening output, ML has taken...
Through the Lens of a Lead Discovery Scientist: Enabling Hit Identification Through DNA-Encoded Libraries
The phrase “you miss 100% of the shots you don’t take” was originally coined by Wayne Gretzky about scoring goals...
A Year of Driving Small Molecule Discovery
2022 was a big year here at X-Chem, so as we embark into 2023 it seems like a good time...
The 10th International Symposium on DNA-Encoded Chemical Libraries
Earlier this month I had the pleasure of attending the 10th International Symposium on DNA-Encoded Chemical Libraries (informally referred to...
New Directions in DEL Research
At X-Chem, we make it a priority to stay engaged with the latest advances in DNA-encoded library (DEL) technology and...
Solution DEL and Bead DEL: Two Tools for Advancing Drug Discovery
In 1992, the late professors Brenner and Lerner were the first to publish the concept of encoding synthetic chemistry with...