Blog
Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...
Blog
Focusing on building blocks and properties is the best way to design better DNA-Encoded Libraries (DELs)
It seems to be a common experience. Your new drug discovery project has accessed a DEL screen and you’re eagerly...
Blog
Applying DNA-Encoded Chemistry to the Discovery of Irreversible Covalent Inhibitors
Some of the most commonly used drugs elicit their therapeutic effects by forming covalent bonds with their targets; examples include...
Blog
Proof of Concept: DEL for PROTACs
DNA-Encoded Chemical Library Screening Is a Great Tool for Identifying Novel Binders Suitable for Bispecific Degraders The Value of DEL...
Blog
Truncations, Side Products and Truth in Labeling for DNA-Encoded Libraries: A Cautionary Tale
Did you ever search a library catalog, dutifully note the location of a book that is allegedly not checked out,...