From Hit to Nomination with One Cohesive Engine
CandidateBuilder is X-Chem’s most advanced engagement model. An end-to-end discovery solution for teams seeking a clear path from validated hit to IND-ready candidate. This program includes the full scope of HitBuilder and LeadBuilder, then goes further, layering in multiparameter optimization, ADME and DMPK refinement, and the supporting data needed to advance a compound with confidence.
You’ll work with the same multidisciplinary team across every phase, ensuring that design rationale, data interpretation, and project strategy are consistent and cohesive throughout. The result is more than just a candidate. It’s a smarter, faster, and more informed path to development.
Integrated Capabilities that Drive Real Progress
CandidateBuilder connects the dots between chemistry, computation, and data interpretation; delivering compound series that are scientifically sound and strategically aligned with your program goals.
- Continuation and expansion of prioritized hit and lead series
- Entry into formal lead optimization with multi-round analog design
- Iterative DMTA cycles with rapid synthesis and clear decision points
- Multiparameter profiling: potency, selectivity, solubility, permeability and metabolic stability
- Synthesis of 100 or more analogs across multiple refinement stages
- Structure–property analysis and SAR mapping informed by DEL data
- Modeling support from ArtemisAI and custom algorithms grounded in internal datasets
- In vitro and in silico ADME screening, PK prediction and off-target liability reduction
- Guidance for candidate selection and supporting data for development transition
Why Discovery Teams Choose CandidateBuilder
Continuity That Reduces Risk
The same X-Chem team that helps identify your hits also designs and refines your lead series. That means fewer handoffs, tighter feedback loops and better long-term outcomes.
Real-Time Optimization
Every compound is assessed not just for potency, but for developability. From the start, your candidate is built with the end in mind—guided by data, modeled for risk and optimized for success.
Predictive Power at Scale
Our approach integrates massive DEL-derived datasets with structure-based design, AI modeling and proprietary scoring functions. This unique combination surfaces insights traditional programs miss.
A Platform Refined by Experience
CandidateBuilder reflects the collective expertise of hundreds of discovery programs and more than a dozen clinical candidates. It’s not theoretical—it’s proven.
Aligned for IND Readiness
From synthetic feasibility to PK insight, every decision is made with the next stage in mind. This isn’t a handoff to another CRO. It’s your team building a real candidate, with data to support your next milestone.
Reduced Financial Risk
X-Chem’s transparent, fixed-price cost model shares the risk, with success-based payments based on pre-agreed milestones. We succeed together.
Built for Programs That Need More Than Just Molecules
This model is a strong fit if:
- You’re preparing for IND-enabling studies and need a nomination-ready candidate
- You’ve completed early-stage screening and are ready to optimize for properties and liability
- You lack internal resources to run multi-round optimization or profile dozens of analogs
- You need modeling, chemistry, and DMPK to work in lockstep – not in silos
- You’re seeking to avoid false starts and wasted synthesis cycles by using the full dataset up front
- You want payments based on success, not time taken or materials used
Is CandidateBuilder Right for You?
This program is ideal for discovery teams ready to transition from promising leads to fully optimized candidates. It may be the right fit if:
- You’re aiming to nominate a small molecule for development
- You need comprehensive chemistry, modeling, and property optimization support
- You want a partner who can manage iterative design and synthesis across multiple rounds
- You’re preparing for IND-enabling activities and require supporting data
- You value scientific continuity and cohesive program management
