Proximity Labeling: DEL Selection Without Capturing the Target
DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly...
Targeted Protein Degradation & Molecular Glues
X-Chem Is Driving Protein Degradation Discovery Targeted protein degradation (TPD) leverages the ubiquitin-proteosome system to induce degradation of specific proteins...
GPCR Discovery
X-Chem’s DEL ScreeningFinds the Target There are over 800 G-protein coupled receptors (GPCRs) encoded in the human genome, and approximately...
Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...
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Immense Opportunities Are Within Reach Please reach out to X-Chem for additional information on our services. For career and internship...
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Anglais Français X-Chem est votre partenaire pour la découverte de petites molécules X-Chem est le partenaire dont vous avez besoin...
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Associate Scientist (Montreal, Canada)
X-Chem is seeking a candidate for the position of Associate Scientist. The Associate Scientist will work within a project team structure, design and execute synthetic routes and troubleshoot when needed. Job Code -INT2102 (Use Job Code in subject line of all communications)
Research Scientist (Montreal, Canada)
X-Chem is seeking a candidate for the position of Research Scientist. The Research Scientist will work independently within a project team structure, design and execute synthetic routes and troubleshoot when needed. Job Code -INT2101 (Use Job Code in subject line of all communications)