Advancing Small Molecules Against Protein-Protein Interactions
Protein–protein interactions remain one of the most challenging target classes in drug discovery. Their large, flat, and hydrophobic surfaces often make them unsuitable for traditional small molecule approaches, and peptide-based mimics rarely lead to clinically viable drugs.
X-Chem applies DNA-encoded library screening with exceptional diversity and scale to identify novel modulators capable of disrupting these complex interactions.
The Proof is in the Success of Our Partners
Small Molecules with Novel Modes Action
X-Chem’s DEL platform supports the discovery of PPI modulators with unprecedented modes of action, driving discovery in directions that other screening technologies cannot. In collaboration with Bayer, we used our platform to identify an inhibitor of a bromodomain target, ATAD2, which induced improper homodimerization of the target rendering it inactive. This resulted in a highly selective inhibitor which does not perturb closely related family members of ATAD2, demonstrating the power of DEL screening for finding molecules with unique binding modes to modulate PPIs.
Advancing from DEL Screen to Candidate: PPI Success Story
DEL screening for PPIs can yield tractable small molecule hits in situations where traditional hit identification (HTS, fragment screening) are unsuccessful. In one example, X-Chem’s DELcore library collection enabled the unprecedented discovery of potent small molecule inhibitors toward a key pro-inflammatory PPI, springboarding our partner’s program into clinical trials.
X-Chem’s PPI Drug Discovery Services Deliver Exactly What You Need
Our proprietary methods deliver more hits faster — even against previously “undruggable” targets like PPIs.
Using our DEL technology and the guidance of our industry-leading experts you can find your PPI project’s best screening solution — all with no downstream financial obligations.
From PPIs to covalent inhibitors and every class in between, whatever your DEL screening needs, X-Chem delivers solutions that accelerate your hit-to-lead development journey and catapult your program.
