DEL Screening Methods To Find High-Quality and Structurally Diverse Novel Hits as Starting Points for New GPCR Modulators
DNA-encoded chemical library (DEL) technology is a fast, reliable, and robust method for identifying high-affinity, drug-like compounds for a wide range of targets and target classes including GPCRs. Here, we describe using a DEL deck consisting of >100 billion compounds to discover high-quality, functional, and structurally novel hits for several GPCR targets. Key considerations to the design of a successful hit identification campaign and follow-up optimization are discussed.
This poster was presented at Discovery on Target 2024 and 9th RSC-BMCS/RSC-SCI Symposium on GPCRs in Medicinal Chemistry
